Clinical Trials

36 enrolled

Brain Neoplasms, Glioblastoma, Recurrence

NCT05843253 2026-04-22

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

120 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT06805305 2026-04-22

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

180 enrolled

Phase 1/2 Not yet recruiting

Glioblastoma

NCT07416188 2026-04-22

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

40 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Nerve Tissue, Recurrence, Central Nervous System Neoplasms

NCT07544992 2026-04-22

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

24 enrolled

Astrocytoma, Glioblastoma

NCT05917145 2026-04-21

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

94 enrolled

Glioblastoma

NCT06069726 2026-04-21

MOAB

80 enrolled

Glioblastoma

NCT06325683 2026-04-21

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Phase 2 Suspended

184 enrolled

Glioblastoma

NCT06336291 2026-04-21

GLIOSTELLA

90 enrolled

Glioblastoma

NCT07462507 2026-04-21

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

104 enrolled

Phase 1 Not yet recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT07541781 2026-04-21

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

45 enrolled

Glioblastoma, Glioma

NCT05557292 2026-04-20

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

Phase 1 Terminated

7 enrolled

Glioblastoma

NCT06894225 2026-04-20

Proof-of-Concept Study of ACT001 in Adult Patients With Recurrent Glioblastoma Harbouring STAT3-High Signature

Phase 2 Suspended

12 enrolled

Phase EARLY_PHASE1 Recruiting

Glioblastoma

NCT07538128 2026-04-20

Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma

10 enrolled

Adenoviridae Infections, Glioblastoma

NCT02287428 2026-04-17

Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

56 enrolled

Phase EARLY_PHASE1 Active not recruiting

Glioblastoma

NCT04656535 2026-04-17

AB154 Combined With AB122 for Recurrent Glioblastoma

46 enrolled

Glioblastoma, Recurrence

NCT04817254 2026-04-17

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 2 Completed

47 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT05698524 2026-04-17

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

24 enrolled

Astrocytoma, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT06466031 2026-04-17

TYR-GLIO

Phase NA Recruiting

189 enrolled

Brain Neoplasms, Glioblastoma

NCT00083512 2026-04-16

Collection of Blood and Urine Samples in Patients Receiving Radiation Therapy for Glioblastoma Multiforme

Recruiting

200 enrolled

Glioblastoma

NCT04998864 2026-04-16

Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients

Completed

3 enrolled

Glioblastoma, Glioma

NCT07042620 2026-04-16

A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery

Phase NA Recruiting

15 enrolled

Glioblastoma, Glioma

NCT07100730 2026-04-16

IPAX BrIGHT

Phase 3 Recruiting

50 enrolled

Brain Neoplasms, Glioblastoma, Neoplasm Recurrence, Local, Neoplasms, Central Nervous System Neoplasms

NCT03451799 2026-04-15

Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma

Phase 1 Completed

21 enrolled

Glioblastoma

NCT04762069 2026-04-15

A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme

252 enrolled

CNSGastrointestinalOther solid neoplasmSarcomaThoracic

Brain Neoplasms, Glioblastoma

NCT05275478 2026-04-15

Safety and Tolerability of TNG908 in Patients With MTAP-deleted Solid Tumors

Phase 1/2 Terminated

110 enrolled

Glioblastoma, Mesothelioma, Sarcoma, Cholangiocarcinoma, Neurofibrosarcoma

NCT06641908 2026-04-15

Anti-GD2 ADC M3554 in Advanced Solid Tumors

52 enrolled

Glioblastoma, Sarcoma

NCT07532031 2026-04-15

APT-HGG

Not yet recruiting

20 enrolled

Glioblastoma, Glioma

NCT01507506 2026-04-14

SPECTRO GLIO

Phase 3 Terminated

180 enrolled

Glioblastoma

NCT01872221 2026-04-14

STEMRI

Phase NA Completed

21 enrolled

Glioblastoma

NCT02866747 2026-04-14

STERIMGLI

Phase 1/2 Completed

108 enrolled

Glioblastoma

NCT06512311 2026-04-14

ATTRACT

Phase NA Recruiting

240 enrolled

Glioblastoma

NCT06607692 2026-04-14

LUPARPED

Phase 1/2 Recruiting

25 enrolled

CNSEndocrineNETSarcoma

Adrenal Cortex Neoplasms, Adrenal Gland Neoplasms, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroblastoma, Paraganglioma, Pheochromocytoma, Recurrence, Osteosarcoma, Sarcoma, Synovial, Esthesioneuroblastoma, Olfactory, Neuroendocrine Tumors

NCT07185880 2026-04-14

STAR-GBM

Phase 1/2 Recruiting

36 enrolled

Glioblastoma

NCT07326566 2026-04-14

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

162 enrolled

Brain Neoplasms, Central Nervous System Diseases, Glioblastoma, Glioma

NCT00268385 2026-04-13

Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas

83 enrolled

Phase 2/3 Active not recruiting

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT02152982 2026-04-13

Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

447 enrolled 20 charts

Glioblastoma, Gliosarcoma

NCT02381886 2026-04-13

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

CNSGastrointestinalMyeloidOther hematologic neoplasm

166 enrolled

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT02800486 2026-04-13

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

37 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT03581292 2026-04-13

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

38 enrolled 13 charts

Astrocytoma, Glioblastoma, Glioma

NCT03911388 2026-04-13

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

24 enrolled

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT03919071 2026-04-13

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

58 enrolled

Astrocytoma, Glioblastoma, Glioma

NCT04145115 2026-04-13

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

37 enrolled

Phase 1/2 Active not recruiting

Astrocytoma, Glioblastoma

NCT04528680 2026-04-13

SC9/ABX

57 enrolled

Glioblastoma, Gliosarcoma

NCT04988750 2026-04-13

Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients

Phase NA Completed

7 enrolled

Brain Neoplasms, Glioblastoma, Glioma

NCT05168423 2026-04-13

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM

67 enrolled

Glioblastoma

NCT05432804 2026-04-13

Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

Phase 1/2 Suspended

97 enrolled

Glioblastoma

NCT06419946 2026-04-13

Lomustine in Addition to Standard of Care in Patients With MGMT Methylated Glioblastoma

Phase 3 Recruiting

200 enrolled