Clinical Trials

153 enrolled 12 charts

Neuroblastoma

NCT06172296 2026-04-14

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

478 enrolled

Neuroblastoma, Ganglioneuroblastoma

NCT03786783 2026-04-13

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

42 enrolled 12 charts

Ganglioneuroblastoma

NCT02595905 2026-04-08

Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases

344 enrolled 11 charts

BreastCNS

Brain Neoplasms, Breast Neoplasms, Triple Negative Breast Neoplasms

NCT03126916 2026-02-27

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

750 enrolled

Phase EARLY_PHASE1 Recruiting

Neuroblastoma, Ganglioneuroblastoma

NCT06942039 2026-02-27

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

15 enrolled

Medulloblastoma, Neuroblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT05382338 2026-02-24

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

225 enrolled

Medulloblastoma

NCT02724579 2026-02-17

Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

45 enrolled

Phase 4 Active not recruiting

Medulloblastoma

NCT02875314 2026-02-12

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

250 enrolled

Medulloblastoma

NCT05535166 2026-02-12

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

Phase 2 Recruiting

130 enrolled

Brain Neoplasms, Medulloblastoma

NCT00336024 2026-01-23

Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

91 enrolled 24 charts

Medulloblastoma

NCT01175356 2026-01-23

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

99 enrolled 11 charts

Neuroblastoma, Ganglioneuroblastoma

NCT00602667 2026-01-13

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma

293 enrolled 89 charts

Phase 2/3 Active not recruiting

Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT04711824 2025-12-23

SOLARA

Phase 1/2 Recruiting

41 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT02066220 2025-12-04

International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

360 enrolled

Brain Neoplasms, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT01878617 2025-11-13

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

660 enrolled

Brain Neoplasms, Medulloblastoma, Infratentorial Neoplasms, Neuroectodermal Tumors, Primitive

NCT04402073 2025-10-23

PersoMed-I

Phase 2 Terminated

20 enrolled

Phase 1 Active not recruiting

Medulloblastoma

NCT05599984 2025-10-20

Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors

288 enrolled

CNSEndocrineThoracic

Neoplasms, Central Nervous System Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT07138001 2025-08-22

Phase 2 Clinical Trial of KH617

Phase 2 Not yet recruiting

60 enrolled

Phase 3 Active not recruiting

Glioblastoma

NCT00392327 2025-06-13

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

379 enrolled 29 charts

Medulloblastoma

NCT03274414 2025-05-16

A Clinical Trial of Endoscopic Surgery Followed by Chemotherapy and Proton Radiation for the Treatment of Tumors in the Sinus and Nasal Passages

3 enrolled 4 charts

Adenocarcinoma, Carcinoma, Squamous Cell, Carcinoma, Adenoid Cystic, Paranasal Sinus Neoplasms, Esthesioneuroblastoma, Olfactory

NCT05012254 2025-04-09

NIVIPI-Brain

71 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms

NCT00085735 2025-01-14

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma

549 enrolled 32 charts

Medulloblastoma

NCT01798004 2024-07-15

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

150 enrolled 9 charts

Neuroblastoma, Ganglioneuroblastoma

NCT00085202 2024-02-08

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

416 enrolled 16 charts

Central Nervous System Neoplasms, Rhabdoid Tumor

NCT03684811 2023-11-18

A Study of FT-2102 in Patients With Advanced Solid Tumors and Gliomas With an IDH1 Mutation

Phase 1/2 Completed

93 enrolled 24 charts

CNSGastrointestinal

Bile Duct Neoplasms, Glioblastoma, Carcinoma, Hepatocellular, Cholangiocarcinoma

NCT00003309 2023-06-22

Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer

33 enrolled

CNSGenitourinaryGynecologic

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT04851834 2022-12-20

NTX-301 Monotherapy in Advanced Solid Tumours and in Combination With Platinum-based Chemotherapy in Advanced Ovarian & Bladder Cancer and in Combination With Temozolomide in High-grade Glioma

Phase 1/2 Terminated

12 enrolled

Urinary Bladder Neoplasms, Glioma, Ovarian Neoplasms

NCT00567567 2022-04-28

Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma

665 enrolled 26 charts

Neuroblastoma

NCT00867178 2022-01-13

Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System

33 enrolled

Phase EARLY_PHASE1 Terminated

Medulloblastoma, Pinealoma

NCT02212574 2021-11-05

Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma

6 enrolled 6 charts

Medulloblastoma

NCT02185352 2021-05-07

A-Plus

Phase 2 Unknown

120 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT01704716 2020-10-23

High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

3,300 enrolled

Neuroblastoma

NCT00498979 2020-07-24

Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

22 enrolled

CNSDermatologicSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Melanoma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT00058370 2020-05-11

Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma

Phase NA Completed

6 enrolled 8 charts

Medulloblastoma, Central Nervous System Neoplasms

NCT00006036 2020-04-06

Liposomal Lurtotecan Plus Cisplatin in Treating Patients With Advanced or Metastatic Solid Tumors

CNSGynecologicHead & NeckThoracic

14 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Neoplasms, Nasopharyngeal Neoplasms, Ovarian Neoplasms, Esthesioneuroblastoma, Olfactory, Small Cell Lung Carcinoma

NCT01614132 2020-03-31

NOA-07

Phase 1/2 Completed

33 enrolled

Medulloblastoma, Neoplasms, Neuroectodermal Tumors

NCT00578864 2020-03-27

PEPI

13 enrolled 7 charts

Neuroblastoma

NCT02786719 2020-03-12

SPRING

Phase NA Completed

13 enrolled 13 charts

Neuroblastoma

NCT01014767 2019-08-20

Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors

Phase 3 Terminated

27 enrolled 1 chart

Brain Neoplasms, Choroid Plexus Neoplasms

NCT00031590 2019-04-25

Low-Dose Radiation and Combination Chemotherapy Following Surgery in Children With Newly Diagnosed Medulloblastoma

Phase 2 Terminated

30 enrolled 5 charts

Brain Neoplasms, Medulloblastoma, Central Nervous System Neoplasms

NCT00085098 2018-09-07

Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor

24 enrolled 9 charts

Brain Neoplasms, Central Nervous System Neoplasms

NCT00470366 2017-11-28

Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors

CNSGenitourinaryGynecologic

60 enrolled 11 charts

Testicular Germ Cell Tumor, Dysgerminoma, Ovarian Neoplasms, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Carcinoma, Embryonal, Seminoma, Endodermal Sinus Tumor

NCT00808899 2017-05-30

Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk Neuroblastoma

Phase 2 Terminated

4 enrolled 5 charts

Neuroblastoma

NCT03042429 2017-02-06

NB2004-HR

360 enrolled

Neuroblastoma

NCT00003996 2016-12-07

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

93 enrolled

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003621 2016-07-14

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Anaplastic Astrocytoma

29 enrolled

Astrocytoma, Central Nervous System Neoplasms

NCT02771743 2016-05-24

Response-based Treatment of High-risk Neuroblastoma

Phase 2 Unknown

54 enrolled

Neuroblastoma

NCT00084838 2015-12-24

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

25 enrolled 24 charts