Clinical Trials

CNSGastrointestinalGynecologic

272 enrolled

Ovarian Neoplasms, Central Nervous System Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT04106219 2026-04-21

A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma

71 enrolled

Epilepsy, Neuroblastoma

NCT06326411 2026-04-20

NST-628

230 enrolled

CNSDermatologic

Glioma, Melanoma, Neoplasms

NCT06641908 2026-04-15

Anti-GD2 ADC M3554 in Advanced Solid Tumors

52 enrolled

CNSSarcoma

Glioblastoma, Sarcoma

NCT02381886 2026-04-13

A Study of IDH305 in Patients With Advanced Malignancies That Harbor IDH1R132 Mutations

CNSGastrointestinalMyeloidOther hematologic neoplasm

166 enrolled

Astrocytoma, Glioblastoma, Glioma, Leukemia, Myelodysplastic Syndromes, Oligodendroglioma, Leukemia, Myeloid, Acute, Cholangiocarcinoma

NCT06253871 2026-04-13

A Phase 1/1b Study of IAM1363 in HER2 Cancers

BreastCNSGastrointestinalThoracic

383 enrolled

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasms, Stomach Neoplasms

NCT07497373 2026-04-03

JL15003

17 enrolled

Glioblastoma

NCT06650605 2026-03-31

CITADEL-123

7 enrolled

Glioblastoma

NCT04762602 2026-03-27

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

42 enrolled 26 charts

CNSGastrointestinal

Glioma, Cholangiocarcinoma

NCT05303467 2026-03-27

FRONTIER

36 enrolled

Glioblastoma

NCT05355701 2026-03-27

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

CNSDermatologicHead & NeckThoracic

267 enrolled

Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Thyroid Neoplasms

NCT05538130 2026-03-27

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT06482905 2026-03-24

Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

52 enrolled

Glioma

NCT05283330 2026-03-20

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

BreastCNSGastrointestinalGenitourinaryGynecologicThoracic

48 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Glioblastoma, Neoplasm Metastasis, Prostatic Neoplasms, Recurrence, Colorectal Neoplasms

NCT07464925 2026-03-20

A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

30 enrolled

Glioblastoma, Glioma

NCT03478462 2026-03-18

CLOVER-2

CNSGenitourinaryLymphoidSarcoma

30 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Glioma, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04678648 2026-03-18

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

CNSGastrointestinalThoracic

134 enrolled

Colonic Neoplasms, Glioblastoma, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Disease Progression

NCT05610891 2026-03-18

Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG

50 enrolled

Glioma

NCT07480941 2026-03-18

DUAL-CAR-NK-GB

36 enrolled

Glioblastoma, Glioma

NCT05916313 2026-03-17

A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3

18 enrolled

Glioma

NCT05109728 2026-03-16

A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

65 enrolled

Glioblastoma

NCT07472790 2026-03-16

A Study on the Novel Oncolytic Virus Combined With PD-1 Inhibitor in the Treatment of Recurrent High-grade Glioma

15 enrolled

Glioma

NCT05484622 2026-03-12

Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma

60 enrolled

Astrocytoma, Oligodendroglioma

NCT07455045 2026-03-06

A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)

40 enrolled

Glioblastoma, Glioma

NCT04895748 2026-03-03

DFF332 as a Single Agent and in Combination With Everolimus & Immuno-Oncology Agents in Advanced/Relapsed Renal Cancer & Other Malignancies

CNSEndocrineGenitourinary

40 enrolled

Hereditary leiomyomatosis and renal cell cancer, Carcinoma, Renal Cell, von Hippel-Lindau Disease, Paraganglioma, Pheochromocytoma

NCT07441707 2026-03-02

A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain Tumours

6 enrolled

Low-grade Glioma

NCT05101148 2026-02-23

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

24 enrolled

Neurofibromatosis 1

NCT05938387 2026-02-18

Safety and Tolerability of CVGBM in Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma or Astrocytoma

37 enrolled

Glioblastoma

NCT02073994 2026-02-17

Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation

CNSGastrointestinalSarcoma

174 enrolled

Chondrosarcoma, Glioma, Cholangiocarcinoma

NCT02481154 2026-02-17

Study of Orally Administered AG-881 in Patients With Advanced Solid Tumors, Including Gliomas, With an IDH1 and/or IDH2 Mutation

95 enrolled

Glioma

NCT03343197 2026-02-17

Study of AG-120 and AG-881 in Subjects With Low Grade Glioma

49 enrolled

Glioma

NCT03030066 2026-02-04

Study of DS-1001b in Patients With Gene IDH1-Mutated Gliomas

47 enrolled

Glioma

NCT05739942 2026-02-03

Dose Finding Study of [177Lu]Lu-NeoB in Newly Diagnosed Glioblastoma and in Recurrent Glioblastoma

40 enrolled

Glioblastoma

NCT04590235 2026-01-30

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

32 enrolled

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT05627323 2026-01-29

CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma

42 enrolled

Glioblastoma

NCT05081180 2026-01-23

Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

17 enrolled

Neoplasms, Central Nervous System Neoplasms

NCT07361705 2026-01-23

Zorifertinib With Osimertinib for NSCLC With Meningeal Progression

42 enrolled

Meningeal Carcinomatosis

NCT04544995 2026-01-21

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

47 enrolled 43 charts

CNSSarcoma

Neoplasms, Neuroblastoma, Osteosarcoma

NCT05450744 2026-01-21

IPAX-2

12 enrolled

Glioblastoma, Neoplasms

NCT06458712 2026-01-16

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

90 enrolled

Kenny-Caffey syndrome, Type 1, Brain Neoplasms

NCT06357377 2026-01-14

A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

12 enrolled

Choroid Plexus Carcinoma, Glioma, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT05977322 2025-12-24

A Phase I Study of [177Lu]Lu-FF58 in Patients With Advanced Solid Tumors.

24 enrolled

CNSGastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Neoplasms, Glioblastoma, Pancreatic Neoplasms, Stomach Neoplasms

NCT03423628 2025-12-22

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

180 enrolled

Brain Neoplasms, Glioblastoma, Inhibition, Psychological, Meningeal Neoplasms, Hereditary Sensory and Autonomic Neuropathies

NCT04541082 2025-12-18

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

102 enrolled

CNSSarcoma

Typical Teratoid Rhabdoid Tumor, Astrocytoma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma

NCT06441331 2025-12-17

KinLET

CNSEndocrineGastrointestinalLymphoidNETSarcoma

20 enrolled

Gastro-enteropancreatic neuroendocrine tumor, Lymphoma, Rhabdomyosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroendocrine Tumors

NCT07244835 2025-12-08

A Study of DEG6498 in Participants With Solid Tumors

CNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

100 enrolled

Glioblastoma, Carcinoma, Hepatocellular, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Neurofibrosarcoma

NCT06961565 2025-12-04

PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform Neurofibromas

56 enrolled

Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT07254845 2025-11-28

A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS

30 enrolled

Brain Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement