NCT04418167 2025-09-03JSI-1187-01 Monotherapy and in Combination With Dabrafenib for Advanced Solid Tumors With MAPK Pathway MutationsJS InnoPharm, LLCPhase 1 Suspended71 enrolled
NCT02083354 2022-02-01Study to Investigate the Objective Response Rate of Dabrafenib in Combination With Trametinib in Subjects With BRAF V600 Mutation-Positive MelanomaNovartisPhase 2 Completed77 enrolled 43 charts
NCT02110355 2021-03-26A Phase 1b/2a Study Evaluating AMG 232 in Metastatic MelanomaKartos Therapeutics, Inc.Phase 1 Completed31 enrolled
NCT01072175 2019-07-05Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212NovartisPhase 2 Completed430 enrolled 61 charts
NCT02314143 2019-02-18Phase II Biomarker Study Comparing the Combination of BRAF Inhibitor Dabrafenib With MEK Inhibitor Trametinib Versus the Combination After Monotherapy With Dabrafenib or TrametinibGlaxoSmithKlinePhase 2 Terminated48 enrolled 20 charts
NCT01954043 2017-11-14A Pharmacokinetics (PK) Study of the Effects Rabeprazole and Rifampin on Dabrafenib in Subjects With BRAF V600 Mutation Positive TumorsGlaxoSmithKlinePhase 1 Completed23 enrolled
NCT01227889 2017-10-04A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) MelanomaGlaxoSmithKlinePhase 3 Completed251 enrolled 21 charts
NCT02082665 2017-07-24Effects of Dabrafenib on the Single Dose Pharmacokinetics (PK) of Rosuvastatin and MidazolamGlaxoSmithKlinePhase 1 Completed6 enrolled