Clinical Trials

80 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04521686 2026-04-22

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

200 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Breast Neoplasms, Chondrosarcoma, Colonic Neoplasms, Glioblastoma, Glioma, Melanoma, Prostatic Neoplasms, Thyroid Neoplasms, Central Nervous System Neoplasms, Cholangiocarcinoma

NCT05816785 2026-04-22

Pilot Study of Imatinib Cetuximab Combo for H & N Cancer

Phase EARLY_PHASE1 Active not recruiting

15 enrolled

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06308913 2026-04-22

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

12 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT06356272 2026-04-22

Oropharynx (OPX) Biomarker Trial

Recruiting

560 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Thyroid Neoplasms

NCT06525220 2026-04-22

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Phase 3 Recruiting

700 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Diseases

NCT06961084 2026-04-22

Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

62 enrolled

Phase 1/2 Not yet recruiting

Thyroid Neoplasms

NCT06991738 2026-04-22

177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer

18 enrolled

Thyroid Neoplasms

NCT07085091 2026-04-22

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

GastrointestinalHead & NeckThoracic

170 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT07320820 2026-04-22

QoL in LSSC

Not yet recruiting

120 enrolled

Agnosia, Laryngeal Neoplasms, Patient Satisfaction

NCT07343596 2026-04-22

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

Phase NA Recruiting

20 enrolled

Mouth Neoplasms

NCT07417605 2026-04-22

POLARIS

Recruiting

180 enrolled

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07540390 2026-04-22

GAPP Induction and Concurrent Chemoradiotherapy for High-risk Locoregionally Advanced NPC.

442 enrolled

Nasopharyngeal Carcinoma

NCT07543887 2026-04-22

EECRTKI

Completed

15 enrolled

Phase 2 Not yet recruiting

Thyroid Diseases, Thyroid Neoplasms

NCT07545083 2026-04-22

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC)

26 enrolled

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07545837 2026-04-22

Health and Wellness Coaching to Improve Adherence to Healthy Habits and Treatment Plans in Papillary and Follicular Thyroid Cancer Survivors

20 enrolled

Thyroid Cancer, Papillary, Adenocarcinoma, Follicular

NCT07546383 2026-04-22

A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase NA Recruiting

32 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT01627093 2026-04-21

Medical Data Collection of Patients With Head and Neck Cancer Treated With Proton Therapy

Active not recruiting

450 enrolled

Head and Neck Carcinoma

NCT03389477 2026-04-21

Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

26 enrolled 12 charts

Phase NA Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04544046 2026-04-21

Supportive Oncology Care At Home RCT

300 enrolled

GastrointestinalHead & NeckLymphoid

Head and Neck Neoplasms, Lymphoma, Pancreatic Neoplasms, Rectal Neoplasms

NCT05537740 2026-04-21

A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors

Phase 1 Active not recruiting

129 enrolled

BreastDermatologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Recurrence, Triple Negative Breast Neoplasms

NCT05786924 2026-04-21

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Phase 1/2 Recruiting

554 enrolled

CNSGastrointestinalHead & NeckMyeloidThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Histiocytosis

NCT06167291 2026-04-21

Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)

8 enrolled

Phase NA Active not recruiting

Oropharyngeal Neoplasms

NCT06187103 2026-04-21

Evaluation of Improved Onboard Patient Imaging

40 enrolled

BreastGastrointestinalGynecologicHead & NeckThoracic

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Pelvic Neoplasms

NCT07020117 2026-04-21

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

BreastHead & NeckThoracic

150 enrolled

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT07029373 2026-04-21

Plasma Calcitonin Gene-Related Peptide (CGRP) Levels in Patients With Head and Neck Malignancies Undergoing Radiotherapy

Completed

23 enrolled

Head and Neck Neoplasms

NCT07255482 2026-04-21

Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial

Active not recruiting

5,000 enrolled

Disease, Thyroid Neoplasms, Thyroid Nodule

NCT07360314 2026-04-21

Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

BreastGastrointestinalGynecologicHead & Neck

138 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Ovarian Neoplasms, Stomach Neoplasms

NCT07444723 2026-04-21

Accuracy of 18F-Fluorocholine PET/MR and NeuroEXPLORER PET/CT Imaging for Localization of Parathyroid Tumors

Phase 2/3 Recruiting

193 enrolled

Parathyroid Neoplasms, Multiple Endocrine Neoplasia Type 1, Hyperparathyroidism, Primary

NCT00001160 2026-04-20

Studies on Tumors of the Thyroid

Recruiting

2,500 enrolled

Thyroid cancer, Hurthle cell, Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular

NCT03485209 2026-04-20

innovaTV 207

GastrointestinalHead & NeckThoracic

350 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT03841617 2026-04-20

The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

30 enrolled

Neoplasm Metastasis, Thyroid Neoplasms

NCT04266093 2026-04-20

Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

Enrolling by invitation

1,000 enrolled

GynecologicHead & Neck

Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Squamous Intraepithelial Lesions of the Cervix

NCT04389632 2026-04-20

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

GastrointestinalGenitourinaryGynecologicHead & NeckThoracic

1,006 enrolled

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Ovarian Neoplasms, Stomach Neoplasms

NCT04927416 2026-04-20

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

54 enrolled

Phase 1 Active not recruiting

Neoplasm Metastasis, Thyroid Neoplasms

NCT05068102 2026-04-20

A Study to Test How BI 765063 and BI 770371 Are Taken up in Tumours of People With Different Types of Advanced Cancer Who Are Also Taking Ezabenlimab

14 enrolled

DermatologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT05208762 2026-04-20

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

BreastGastrointestinalGynecologicHead & NeckThoracic

714 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Stomach Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05237960 2026-04-20

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

34 enrolled

Erythroplasia, Leukoplakia, Oral

NCT05852223 2026-04-20

NePenThe

25 enrolled

Differentiated Thyroid Cancer

NCT06150664 2026-04-20

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

BreastDermatologicHead & NeckLymphoidThoracic

85 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Hodgkin Disease, Melanoma, Triple Negative Breast Neoplasms

NCT06465017 2026-04-20

ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) in Thyroid Cancer

Phase NA Terminated

149 enrolled

Disease, Neoplasms, Thyroid Neoplasms

NCT06465069 2026-04-20

NEXUS-01

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

420 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Ureteral Neoplasms, Urologic Neoplasms, Triple Negative Breast Neoplasms

NCT06568172 2026-04-20

Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer

Phase 3 Recruiting

420 enrolled

DermatologicHead & NeckSarcoma

Eyelid Squamous Cell Carcinoma

NCT06589804 2026-04-20

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Phase 3 Recruiting

158 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT07532356 2026-04-20

Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients

Not yet recruiting

100 enrolled

Phase 1/2 Not yet recruiting

Thyroid Neoplasms

NCT07538206 2026-04-20

Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal Carcinoma

10 enrolled

Phase NA Not yet recruiting

Pathologic Complete Response, Head and Neck Neoplasms

NCT07538934 2026-04-20

A Phase II Prospective, Open-Label, Randomized, Multicenter Study of Kangfu Spray for the Prevention of Radiation-Induced Oral Mucositis in Patients With Oral Malignancies Receiving Intensity-Modulated Radiotherapy

140 enrolled

Mouth Neoplasms

NCT01810913 2026-04-17

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Phase 2/3 Recruiting

613 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT02713269 2026-04-17

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord