Clinical Trials

80 enrolled

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05816785 2026-04-22

Pilot Study of Imatinib Cetuximab Combo for H & N Cancer

15 enrolled

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06308913 2026-04-22

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

12 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT06356272 2026-04-22

Oropharynx (OPX) Biomarker Trial

Recruiting

560 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Thyroid Neoplasms

NCT06961084 2026-04-22

Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

62 enrolled

Thyroid Neoplasms

NCT07320820 2026-04-22

QoL in LSSC

Not yet recruiting

120 enrolled

Agnosia, Laryngeal Neoplasms, Patient Satisfaction

NCT07343596 2026-04-22

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

20 enrolled

Mouth Neoplasms

NCT07417605 2026-04-22

POLARIS

Recruiting

180 enrolled

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07540390 2026-04-22

GAPP Induction and Concurrent Chemoradiotherapy for High-risk Locoregionally Advanced NPC.

442 enrolled

Nasopharyngeal Carcinoma

NCT07543887 2026-04-22

EECRTKI

Completed

15 enrolled

Phase 2 Not yet recruiting

Thyroid Diseases, Thyroid Neoplasms

NCT07545083 2026-04-22

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC)

26 enrolled

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07545837 2026-04-22

Health and Wellness Coaching to Improve Adherence to Healthy Habits and Treatment Plans in Papillary and Follicular Thyroid Cancer Survivors

20 enrolled

Thyroid Cancer, Papillary, Adenocarcinoma, Follicular

NCT07546383 2026-04-22

A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

32 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT01627093 2026-04-21

Medical Data Collection of Patients With Head and Neck Cancer Treated With Proton Therapy

Active not recruiting

450 enrolled

Head and Neck Carcinoma

NCT03389477 2026-04-21

Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

26 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT04544046 2026-04-21

Supportive Oncology Care At Home RCT

GastrointestinalHead & NeckLymphoid

300 enrolled

Head and Neck Neoplasms, Lymphoma, Pancreatic Neoplasms, Rectal Neoplasms

NCT06167291 2026-04-21

Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)

8 enrolled

Oropharyngeal Neoplasms

NCT07029373 2026-04-21

Plasma Calcitonin Gene-Related Peptide (CGRP) Levels in Patients With Head and Neck Malignancies Undergoing Radiotherapy

Completed

23 enrolled

Head and Neck Neoplasms

NCT07255482 2026-04-21

Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial

Active not recruiting

5,000 enrolled

Disease, Thyroid Neoplasms, Thyroid Nodule

NCT05237960 2026-04-20

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

34 enrolled

Erythroplasia, Leukoplakia, Oral

NCT05852223 2026-04-20

NePenThe

25 enrolled

Differentiated Thyroid Cancer

NCT06465017 2026-04-20

ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) in Thyroid Cancer

Phase NA Terminated

149 enrolled

Disease, Neoplasms, Thyroid Neoplasms

NCT07532356 2026-04-20

Integrating Tumor Genomics and Urinary Exosomal Proteomics to Establish a Multi-Layer Biomarker Framework for Early Risk Stratification and Post-Treatment Surveillance in Fresh Thyroid Cancer Patients

Not yet recruiting

100 enrolled

Phase 1/2 Not yet recruiting

Thyroid Neoplasms

NCT07538206 2026-04-20

Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal Carcinoma

10 enrolled

Phase NA Not yet recruiting

Pathologic Complete Response, Head and Neck Neoplasms

NCT07538934 2026-04-20

A Phase II Prospective, Open-Label, Randomized, Multicenter Study of Kangfu Spray for the Prevention of Radiation-Induced Oral Mucositis in Patients With Oral Malignancies Receiving Intensity-Modulated Radiotherapy

140 enrolled

Mouth Neoplasms

NCT02713269 2026-04-17

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

60 enrolled

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT05119296 2026-04-17

Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

12 enrolled

Thyroid Neoplasms

NCT05570851 2026-04-17

Alcohol Cessation Among Head and Neck Cancer Survivors

Phase NA Completed

126 enrolled

Alcohol Drinking, Depression, Head and Neck Neoplasms, Social Isolation, Substance-Related Disorders

NCT06477692 2026-04-17

Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

80 enrolled

Head and Neck Neoplasms

NCT06902623 2026-04-17

Lombardi197

30 enrolled

Oropharyngeal Neoplasms, Tonsillar Neoplasms

NCT06997068 2026-04-17

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Oral Cavity Cancer in a Rural Midwest United States Population

25 enrolled

Mouth Neoplasms

NCT07445048 2026-04-17

Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma

Phase 3 Recruiting

370 enrolled

Phase 2/3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07535567 2026-04-17

NimoBenSeq

386 enrolled

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07536412 2026-04-17

Decision Aid Efficacy in Low Risk Thyroid Cancer

34 enrolled

Phase 3 Active not recruiting

Papillary Thyroid Microcarcinoma, Thyroid Cancer, Papillary, Thyroid Neoplasms

NCT01266044 2026-04-16

Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia

435 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT01709292 2026-04-16

Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer

24 enrolled

Thyroid Cancer, Papillary, Thyroid Neoplasms

NCT02128906 2026-04-16

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

120 enrolled

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT02543320 2026-04-16

Neurofeedback in Decreasing Acute Radiotherapy-Induced Pain in Patients With Head and Neck Cancer

17 enrolled

Head and Neck Carcinoma

NCT02615275 2026-04-16

Bioelectrical Impedance Analysis in Estimating Body Composition in Patients With Stage I-IV Head and Neck Cancer Undergoing Radiation Therapy

50 enrolled

Head and Neck Carcinoma

NCT02662907 2026-04-16

Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy

175 enrolled

Head and Neck Neoplasms

NCT03145077 2026-04-16

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body

1,400 enrolled

Head and Neck Neoplasms, Osteoradionecrosis

NCT03574792 2026-04-16

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Phase 2 Completed

62 enrolled 10 charts

DermatologicHead & Neck

Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

NCT05743569 2026-04-16

3D Specimen Maps for RT Planning

Active not recruiting

13 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06550050 2026-04-16

Clinical and Molecular Features of Oral Premalignancy and Oral Cancer

Recruiting

1,000 enrolled

Mouth Neoplasms

NCT06702033 2026-04-16

MINT-2

142 enrolled

Oropharyngeal Neoplasms

NCT07101432 2026-04-16

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

Phase 1 Recruiting

33 enrolled

Phase 2 Not yet recruiting

Head and Neck Neoplasms

NCT07361133 2026-04-16

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

120 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT07470489 2026-04-16

Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer

12 enrolled

Thyroid Carcinoma, Anaplastic

NCT07532538 2026-04-16

ML-HNC-Risk

Not yet recruiting

3,000 enrolled

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT07532928 2026-04-16

A Bidirectional Study of Individualized Postoperative Adjuvant Treatment Decision Model for Locally Advanced Head and Neck Squamous Cell Carcinoma Based on Multimodal Dynamic Data

Enrolling by invitation

571 enrolled