Clinical Trials Browser

OTHER × Interventional × Head & Neck × Clear all

NCT04080804 2026-04-22

Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05816785 2026-04-22

Pilot Study of Imatinib Cetuximab Combo for H & N Cancer

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06308913 2026-04-22

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT06961084 2026-04-22

Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

Phase 2 Recruiting

Thyroid Neoplasms

NCT07343596 2026-04-22

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

Phase NA Recruiting

Mouth Neoplasms

NCT07540390 2026-04-22

GAPP Induction and Concurrent Chemoradiotherapy for High-risk Locoregionally Advanced NPC.

Phase 3 Not yet recruiting

Nasopharyngeal Carcinoma

NCT07545083 2026-04-22

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC)

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07545837 2026-04-22

Health and Wellness Coaching to Improve Adherence to Healthy Habits and Treatment Plans in Papillary and Follicular Thyroid Cancer Survivors

Phase NA Not yet recruiting

EndocrineHead & Neck

Thyroid Cancer, Papillary, Adenocarcinoma, Follicular

NCT07546383 2026-04-22

A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase NA Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT03389477 2026-04-21

Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

Phase 2 Active not recruiting

26 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT04544046 2026-04-21

Supportive Oncology Care At Home RCT

Phase NA Active not recruiting

GastrointestinalHead & NeckLymphoid

Head and Neck Neoplasms, Lymphoma, Pancreatic Neoplasms, Rectal Neoplasms

NCT06167291 2026-04-21

Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)

Phase 2 Active not recruiting

Oropharyngeal Neoplasms

NCT05237960 2026-04-20

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Phase 2 Active not recruiting

Erythroplasia, Leukoplakia, Oral

NCT05852223 2026-04-20

NePenThe

Phase 2 Recruiting

EndocrineHead & Neck

Differentiated Thyroid Cancer

NCT06465017 2026-04-20

ImmunoPET Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) in Thyroid Cancer

Phase NA Terminated

Disease, Neoplasms, Thyroid Neoplasms

NCT07538206 2026-04-20

Vebectotamab Vedotin Combined With Pucotelimab in the Treatment of Locally Advanced Laryngeal Carcinoma

Phase 1/2 Not yet recruiting

Pathologic Complete Response, Head and Neck Neoplasms

NCT07538934 2026-04-20

A Phase II Prospective, Open-Label, Randomized, Multicenter Study of Kangfu Spray for the Prevention of Radiation-Induced Oral Mucositis in Patients With Oral Malignancies Receiving Intensity-Modulated Radiotherapy

Phase NA Not yet recruiting

Mouth Neoplasms

NCT02713269 2026-04-17

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

Phase 2 Active not recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT05119296 2026-04-17

Phase II Trial of Pembrolizumab in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

Phase 2 Active not recruiting

Thyroid Neoplasms

NCT05570851 2026-04-17

Alcohol Cessation Among Head and Neck Cancer Survivors

Phase NA Completed

Alcohol Drinking, Depression, Head and Neck Neoplasms, Social Isolation, Substance-Related Disorders

NCT06477692 2026-04-17

Invert-Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy

Phase 2 Recruiting

Head and Neck Neoplasms

NCT06902623 2026-04-17

Lombardi197

Phase NA Recruiting

Oropharyngeal Neoplasms, Tonsillar Neoplasms

NCT06997068 2026-04-17

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Oral Cavity Cancer in a Rural Midwest United States Population

Phase 2 Recruiting

Mouth Neoplasms

NCT07445048 2026-04-17

Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07535567 2026-04-17

NimoBenSeq

Phase 2/3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07536412 2026-04-17

Decision Aid Efficacy in Low Risk Thyroid Cancer

Phase NA Not yet recruiting

EndocrineHead & Neck

Papillary Thyroid Microcarcinoma, Thyroid Cancer, Papillary, Thyroid Neoplasms

NCT01266044 2026-04-16

Controlled Trial Of Acupuncture To Prevent Radiation-Induced Xerostomia

Phase 3 Active not recruiting

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT01709292 2026-04-16

Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer

Phase 2 Active not recruiting

EndocrineHead & Neck

Thyroid Cancer, Papillary, Thyroid Neoplasms

NCT02128906 2026-04-16

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

Phase 2 Recruiting

Carcinoma, Squamous Cell, Laryngeal Diseases

NCT02543320 2026-04-16

Neurofeedback in Decreasing Acute Radiotherapy-Induced Pain in Patients With Head and Neck Cancer

Phase NA Active not recruiting

Head and Neck Carcinoma

NCT02615275 2026-04-16

Bioelectrical Impedance Analysis in Estimating Body Composition in Patients With Stage I-IV Head and Neck Cancer Undergoing Radiation Therapy

Phase NA Active not recruiting

Head and Neck Carcinoma

NCT02662907 2026-04-16

Cough, Expiratory Training, and Chronic Aspiration After Head and Neck Radiotherapy

Phase NA Active not recruiting

Head and Neck Neoplasms

NCT03145077 2026-04-16

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Diagnosing Osteoradionecrosis in Patients With Head and Neck Cancer That Is Primary, Has Come Back, or Has Spread to Other Places in the Body

Phase NA Recruiting

Head and Neck Neoplasms, Osteoradionecrosis

NCT03574792 2026-04-16

Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy

Phase 2 Completed

62 enrolled 10 charts

DermatologicHead & Neck

Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8

NCT06702033 2026-04-16

MINT-2

Phase 2 Recruiting

Oropharyngeal Neoplasms

NCT07101432 2026-04-16

Phase I Study of Preconditioning Radiation Therapy With IL-15 Transduced TGFBR2 KO CAR.TROP2-engineered Cord Blood-derived NK Cells in Patients With Advanced Head and Neck Cancer (RADIANCE-NK)

Phase 1 Recruiting

Head and Neck Neoplasms

NCT07361133 2026-04-16

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT07470489 2026-04-16

Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer

Phase 2 Not yet recruiting

EndocrineHead & Neck

Thyroid Carcinoma, Anaplastic

NCT00076310 2026-04-15

OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell Cancer

Phase 2 Active not recruiting

50 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT02790853 2026-04-15

Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders

Phase EARLY_PHASE1 Active not recruiting

Mouth Diseases, Mouth Neoplasms

NCT03114462 2026-04-15

Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer

Phase 1 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT03114501 2026-04-15

Dyadic Yoga Intervention for Patient With Head and Neck Cancer Undergoing Radiotherapy and Their Family Caregivers

Phase NA Active not recruiting

Head and Neck Neoplasms

NCT03953352 2026-04-15

GIRAFE

Phase NA Withdrawn

Head and Neck Neoplasms

NCT04003051 2026-04-15

Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies

Phase 2 Recruiting

Head and Neck Neoplasms, Trismus

NCT04208490 2026-04-15

HN-STAR

Phase NA Active not recruiting

Head and Neck Neoplasms

NCT04693377 2026-04-15

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Phase NA Recruiting

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasm Metastasis, Prostatic Neoplasms, Sarcoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT04870762 2026-04-15

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

Phase 2 Recruiting

Maxillary Sinus Neoplasms, Mouth Neoplasms, Parotid Neoplasms, Tongue Neoplasms, Tonsillar Neoplasms

NCT05039801 2026-04-15

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

Phase 1 Recruiting

DermatologicGynecologicHead & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Chondrosarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms

NCT05187091 2026-04-15

SWOAR

Phase 3 Active not recruiting

Deglutition Disorders, Head and Neck Neoplasms

NCT06458036 2026-04-15

RAISE

Phase 2 Recruiting

Neoplasms, Thyroid Neoplasms