Clinical Trials Browser

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT03994796 2026-04-13

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Phase 2 Active not recruiting

50 enrolled

CNS

Brain Neoplasms, Neoplasm Metastasis

NCT04185038 2026-04-13

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Phase 1 Recruiting

90 enrolled

CNS

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05222620 2026-04-13

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Phase 2 Recruiting

90 enrolled

CNS

Brain Neoplasms, Neoplasm Metastasis

NCT06599879 2026-04-13

IPANEMA

Phase NA Recruiting

130 enrolled

CNS

Brain Neoplasms

NCT07505979 2026-04-13

SMART Trial: Cognitive Sparing Brain Radiotherapy for Multiple Brain Metastases

Phase 2 Not yet recruiting

90 enrolled

CNS

Brain Neoplasms

NCT03277638 2026-04-09

Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

Phase 1/2 Active not recruiting

32 enrolled

CNS

Brain Neoplasms, Glioblastoma

NCT05048212 2026-04-09

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

Phase 2 Recruiting

20 enrolled

CNSGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell

NCT06238882 2026-04-09

Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.

Phase NA Recruiting

74 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung

NCT06282874 2026-04-09

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

Phase 4 Active not recruiting

41 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT07134842 2026-04-09

WinGlio-ipi

Phase 1 Recruiting

16 enrolled

CNSSarcoma

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT07520370 2026-04-09

Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor

Phase NA Not yet recruiting

1,370 enrolled

CNS

Brain Neoplasms, Stroke

NCT05987644 2026-04-08

DURABLE

Phase 1/2 Recruiting

56 enrolled

CNSThoracic

Brain Neoplasms, Lung Neoplasms

NCT07206849 2026-04-08

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

Phase 2 Not yet recruiting

79 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma

NCT07248228 2026-04-08

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Phase 2 Not yet recruiting

90 enrolled

CNS

Brain Neoplasms

Clinical Trials

METAPERF

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

PROTONBIOMARKS

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

MRI and Blood Biomarkers for the Prediction of Neurocognitive Decline Following Brain Radiation

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

Window of Opportunity Study of DSP-0390 in Gliomas

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases:

Non-invasive Glioma Characterization Through Molecular Imaging

TARGET-RT

Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases

A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection

Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors

TYR-GLIO

C-SMART vs BE Well for Patients With Brain Tumors

SRS

Study of Letrozole in Recurrent Gliomas

NTS-WBRT in Brain Metastases

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

Sunitinib in Treating Patients With Kidney Cancer That Has Spread to the Brain

A Trial of Increased Dose Intensity Modulated Proton Therapy (IMPT) for High-Grade Meningiomas

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers

Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MR

A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy

TPT CED rHGG

rTMS for Postoperative Brain Tumor Patients

Metabolomic and Epigenetic Profiling of Bodyfluids From Lung and Brain Cancer Receiving Radiation Therapy

Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA

A Simple Walking Program to Enhance Concurrent Chemoradiotherapy Delivery

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

IPANEMA

SMART Trial: Cognitive Sparing Brain Radiotherapy for Multiple Brain Metastases

Laser Interstitial Thermotherapy (LITT) Combined With Checkpoint Inhibitor for Recurrent GBM (RGBM)

A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases

Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.

Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases

WinGlio-ipi

Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor

DURABLE

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)