Clinical Trials

90 enrolled

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT05278208 2026-04-13

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Phase 1/2 Recruiting

65 enrolled

BreastCNSGastrointestinalGenitourinaryHead & Neck

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT05313191 2026-04-13

ReRT

Phase NA Recruiting

1,800 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Neoplasms, Prostatic Neoplasms, Central Nervous System Neoplasms

NCT04732065 2026-03-17

PNOC023

208 enrolled

Ependymoma, Glioblastoma, Central Nervous System Neoplasms

NCT05425004 2026-03-05

Cabozantinib for Patients With Recurrent or Progressive Meningioma

Phase 2 Recruiting

24 enrolled

Meningioma, Central Nervous System Neoplasms

NCT03270059 2026-02-27

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

Phase 2 Recruiting

150 enrolled

Brain Neoplasms, Cranial Nerve Diseases, Central Nervous System Neoplasms

NCT06104488 2026-02-25

A Study of Avutometinib for People With Solid Tumor Cancers

23 enrolled

Phase 1 Not yet recruiting

Brain Neoplasms, Neoplasms, Neuroblastoma, Central Nervous System Neoplasms, Neurofibroma, Plexiform

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

70 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT07378683 2026-01-30

A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery

Phase NA Recruiting

500 enrolled

Surgical Wound Infection, Central Nervous System Neoplasms

NCT05762419 2026-01-28

FUS Etoposide for DMG

Phase 2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Brain Diseases, Brain Neoplasms, Glioma, Nervous System Neoplasms, Central Nervous System Neoplasms

NCT06208657 2026-01-28

Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

Phase 1/2 Recruiting

90 enrolled

CNSLymphoid

Lymphoma, Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT04992013 2026-01-23

Niraparib in Tumors Metastatic to the CNS

20 enrolled

Phase 3 Active not recruiting

Neoplasm Metastasis, Central Nervous System Neoplasms

NCT00887146 2026-01-22

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

305 enrolled

Phase NA Not yet recruiting

Astrocytoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms

NCT07147179 2026-01-22

Short Course Radiotherapy

15 enrolled

Central Nervous System Neoplasms

NCT05835687 2026-01-20

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

48 enrolled

Phase NA Not yet recruiting

Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT06485310 2026-01-20

TECAP

58 enrolled

Phase 2 Active not recruiting

Central Nervous System Neoplasms

NCT00602667 2026-01-13

Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma

293 enrolled 89 charts

Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT06466798 2026-01-08

Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies

Phase 1 Withdrawn

Phase 1 Active not recruiting

Ependymoma, Medulloblastoma, Central Nervous System Neoplasms

NCT03500991 2025-12-17

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

11 enrolled

Phase 1/2 Active not recruiting

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT02932280 2025-12-05

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

14 enrolled

CNSLymphoidOther hematologic neoplasm

Disease, Leukemia, Lymphoma, Recurrence, Central Nervous System Neoplasms

NCT04081701 2025-11-21

DOMINO-START

Phase 4 Recruiting

200 enrolled

CNSEndocrine

Medulloblastoma, Meningioma, Paraganglioma, Pituitary Neoplasms, Central Nervous System Neoplasms, Esthesioneuroblastoma, Olfactory, Hemangioblastoma

NCT05768880 2025-11-20

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

Phase 1 Active not recruiting

72 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Recurrence, Central Nervous System Neoplasms

NCT05720624 2025-10-22

Pharmacodynamic Analyses of Metabolic Agents Following Brain Radiation

Phase 1 Withdrawn

Phase 1/2 Active not recruiting

Central Nervous System Neoplasms

NCT04446962 2025-09-25

LOC-R01

118 enrolled

CNSLymphoid

Lymphoma, Neurologic Manifestations, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms

NCT02442297 2025-09-05

iCAR

Phase 1 Active not recruiting

Brain Neoplasms, Central Nervous System Neoplasms

NCT04977375 2025-09-03

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

Phase 1/2 Recruiting

Brain Neoplasms, Glioblastoma, Glioma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT05308407 2025-08-05

POWER UP: Participating Online While Exercising to Recover Using Play

Phase NA Terminated

17 enrolled

CNSDermatologicLymphoidMyeloidOther hematologic neoplasmPlasma cell

Motor Activity, Neoplasms, Central Nervous System Neoplasms

NCT00935090 2025-07-08

3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer

Recruiting

Pdgfra-Associated Chronic Eosinophilic Leukemia, Congenital Abnormalities, Immunoglobulin Light-chain Amyloidosis, Blast Crisis, Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Leukemia, Leukemia, Hairy Cell, Leukemia, Mast-Cell, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Waldenstrom Macroglobulinemia, Multiple Myeloma, Mycosis Fungoides, Myelodysplastic Syndromes, Myeloproliferative Disorders, Polycythemia Vera, Sezary Syndrome, Thrombocythemia, Essential, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Biphenotypic, Acute, Leukemia, Prolymphocytic, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Neutrophilic, Chronic, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Central Nervous System Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Neoplasms, Plasma Cell, Lymphoma, Extranodal NK-T-Cell, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis, Intraocular Lymphoma

NCT07017816 2025-06-17

JACOB

Phase EARLY_PHASE1 Not yet recruiting

18 enrolled

Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

Phase 2 Completed

50 enrolled

Phase NA Active not recruiting

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT04706676 2025-06-11

INTERACT

132 enrolled

CNSLymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Motor Activity, Neoplasms, Central Nervous System Neoplasms, Metabolic Syndrome

NCT00328458 2025-05-02

EPO906 Plus Radiation Therapy for the Treatment of Cancer Patients

39 enrolled

CNSHead & Neck

Head and Neck Neoplasms, Central Nervous System Neoplasms

NCT00329589 2025-05-02

A Trial Using Velcade Plus Chemoradiation for Central Nervous System, Head and Neck, and Cervical Cancer Patients

CNSGynecologicHead & Neck

54 enrolled

Brain Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Central Nervous System Neoplasms

NCT04479514 2025-05-01

Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy

Phase 2 Completed

14 enrolled 6 charts

Phase NA Active not recruiting

Dermatitis, Neoplasms, Central Nervous System Neoplasms

NCT02100891 2025-03-19

STIR

Phase 2 Terminated

15 enrolled 11 charts

CNSSarcoma

Brain Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Central Nervous System Neoplasms

NCT03496402 2025-03-18

MICCHADO

600 enrolled

CNSOther hematologic neoplasmSarcoma

Leukemia, Neuroblastoma, Rhabdomyosarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral

NCT04023669 2025-02-07

Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors

21 enrolled

Microphthalmia, Isolated, with Coloboma 5, Brain Neoplasms, Medulloblastoma, Central Nervous System Neoplasms

NCT04539574 2025-01-08

An Investigational Scan (7T MRI) for the Imaging of Central Nervous System Tumors

Phase NA Completed

50 enrolled 6 charts

Phase EARLY_PHASE1 Completed

Glioma, Neoplasm Metastasis, Central Nervous System Neoplasms

NCT04217694 2024-11-21

Memantine for the Reduction of Cognitive Impairment After Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

18 enrolled

Central Nervous System Neoplasms

NCT03990597 2024-10-09

StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord

Phase 1 Withdrawn

Ependymoma, Glioma, Medulloblastoma, Pinealoma, Central Nervous System Neoplasms

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

68 enrolled

CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT00884598 2024-05-10

CIRAB

19 enrolled

CNSThoracic

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Central Nervous System Neoplasms

NCT06380387 2024-04-23

Whole Body Metabolism in Children Before and After Treatment of CNS Tumor

Phase NA Recruiting

30 enrolled