Clinical Trials

37 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT03911388 2026-04-13

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Phase 1 Recruiting

24 enrolled

CNSSarcoma

Choroid Plexus Carcinoma, Astrocytoma, Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Cerebellar Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Nervous System Diseases, Nervous System Neoplasms, Oligodendroglioma, Virus Diseases, Central Nervous System Neoplasms, Neuroectodermal Tumors, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor

NCT04185038 2026-04-13

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Phase 1 Recruiting

90 enrolled

Choroid Plexus Carcinoma, Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT04485559 2026-04-13

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

Phase 1 Suspended

50 enrolled

Glioma

NCT05278208 2026-04-13

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Phase 1/2 Recruiting

65 enrolled

Phase 1/2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT07468136 2026-04-13

Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas

33 enrolled

CNSLymphoid

Astrocytoma, Glioblastoma, Glioma, Lymphoma, Follicular, Oligodendroglioma

NCT07521657 2026-04-13

NF118

Phase 2 Not yet recruiting

55 enrolled

Glioblastoma, Glioma, Neurofibromatosis 1

NCT05096481 2026-04-08

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

120 enrolled

Phase 2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Glioma, Medulloblastoma

NCT07206849 2026-04-08

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

79 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Glioma

NCT02104310 2026-04-06

A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas

Active not recruiting

25 enrolled

Glioma

NCT07488754 2026-04-06

Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4)

35 enrolled

Glioblastoma, Glioma

NCT05839379 2026-03-31

Targeted Pediatric High-Grade Glioma Therapy

Recruiting

350 enrolled

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma

NCT07499141 2026-03-30

UFGAG

Completed

41 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Glioblastoma, Glioma

NCT03605550 2026-03-27

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

64 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT03739411 2026-03-27

Hyperpolarized Imaging in Diagnosing Participants With Glioma

Phase 1 Recruiting

140 enrolled

Glioma

NCT06838676 2026-03-27

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

60 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT07074756 2026-03-27

A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

120 enrolled

Glioma

NCT07413796 2026-03-27

NEURO-SUTURE

382 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Meningioma

NCT01743950 2026-03-25

A Phase II Study of Pulse Reduced Dose Rate Radiation Therapy With Bevacizumab

Phase 2 Terminated

49 enrolled 19 charts

Glioblastoma, Glioma

NCT06368310 2026-03-25

FIH Clinical Investigation of Graphene Electrodes for Brain Mapping

10 enrolled

Brain Neoplasms, Glioma

NCT02286167 2026-03-24

GLAD

Phase NA Completed

25 enrolled

Glioblastoma, Glioma

NCT05212272 2026-03-23

MRI in High-Grade Glioma Patients Undergoing Chemoradiation

16 enrolled

Phase NA Not yet recruiting

Glioma

NCT07089758 2026-03-23

A Study for Cerebral Open Flow Microperfusion

6 enrolled

Phase NA Not yet recruiting

Glioblastoma, Glioma

NCT07488780 2026-03-23

Language Network Prehab Via fMRI Neurofeedback

4 enrolled

Phase EARLY_PHASE1 Terminated

Glioma

NCT03796273 2026-03-20

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

15 enrolled

Phase 1 Active not recruiting

Astrocytoma, Glioma, Oligodendroglioma

NCT04573140 2026-03-19

PNOC020

28 enrolled

CNSLymphoid

Brain Neoplasms, Glioblastoma, Glioma, Lymphoma, Follicular

NCT07481721 2026-03-19

APIC-RG

Phase 1 Not yet recruiting

24 enrolled

Glioma

NCT02115074 2026-03-18

FLUVABREX

Phase 1 Completed

20 enrolled

Phase EARLY_PHASE1 Recruiting

Glioma, Recurrence

NCT04655404 2026-03-18

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

15 enrolled

Diffuse Intrinsic Pontine Glioma, Glioma

NCT05500391 2026-03-18

SUR-CAN

CNSEndocrineGastrointestinalNETSarcoma

88 enrolled

Carcinosarcoma, Glioma, Seminoma, Adenocarcinoma, Clear Cell, Carcinoma, Small Cell, Sex Cord-Gonadal Stromal Tumors, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT05577416 2026-03-18

AB-218-IIT-201

Phase EARLY_PHASE1 Completed

14 enrolled