Clinical Trials

200 enrolled

Phase 2 Not yet recruiting

Rectal Neoplasms

NCT07543848 2026-04-22

A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer

20 enrolled

Rectal Neoplasms

NCT02584985 2026-04-21

ETAP

Phase 3 Completed

226 enrolled

Rectal Neoplasms

NCT03516942 2026-04-21

Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment

Active not recruiting

565 enrolled 16 charts

Phase NA Active not recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT04544046 2026-04-21

Supportive Oncology Care At Home RCT

300 enrolled

GastrointestinalHead & NeckLymphoid

Head and Neck Neoplasms, Lymphoma, Pancreatic Neoplasms, Rectal Neoplasms

NCT05009069 2026-04-21

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

58 enrolled

Rectal Neoplasms

NCT05308446 2026-04-21

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

84 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06424522 2026-04-21

A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients

80 enrolled

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT07393048 2026-04-21

ctDNA-MRD-RC

60 enrolled

Rectal Neoplasms

NCT07407647 2026-04-21

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

GastrointestinalGynecologic

25 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT03190941 2026-04-20

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Recruiting

110 enrolled

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03876561 2026-04-20

CONTICARE

Phase NA Terminated

120 enrolled

Rectal Neoplasms

NCT06447662 2026-04-20

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

Phase 1 Recruiting

330 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT06997497 2026-04-20

KANDLELIT-012

Phase 3 Recruiting

477 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT05513742 2026-04-17

COMPANION-003

Phase 2 Completed

49 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07405476 2026-04-17

Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment

38 enrolled

Phase NA Active not recruiting

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07522294 2026-04-17

Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision

20 enrolled

Rectal Neoplasms

NCT07536321 2026-04-17

Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma.

Not yet recruiting

46 enrolled

Rectal Neoplasms

NCT07537998 2026-04-17

Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.

Phase 2/3 Recruiting

160 enrolled

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT02863107 2026-04-16

Young-Onset Colorectal Cancer

Active not recruiting

818 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT06569368 2026-04-16

Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

60 enrolled

Phase NA Active not recruiting

Rectal Neoplasms

NCT03144765 2026-04-15

Multicenter Phase II Study of Transanal TME (taTME)

100 enrolled

Rectal Neoplasms

NCT04104139 2026-04-15

TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

19 enrolled

Rectal Neoplasms

NCT06274190 2026-04-15

Treatable

158 enrolled

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT06831669 2026-04-15

Metabolomics to Predict Treatment Response and Toxicities in Rectal Cancer

250 enrolled

GastrointestinalGynecologicThoracic

Rectal Neoplasms

NCT07458347 2026-04-15

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

Phase 1 Recruiting

145 enrolled

Biliary Tract Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT06205485 2026-04-14

NEO-RT

Phase 3 Recruiting

250 enrolled

Phase 2 Not yet recruiting

Rectal Neoplasms

NCT07527520 2026-04-14

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial

165 enrolled

Rectal Neoplasms

NCT07528209 2026-04-14

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

Phase 3 Recruiting

556 enrolled

Rectal Neoplasms

NCT01822444 2026-04-13

ANGIOPREDICT. ICORG 12-16, V3

Completed

76 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02381561 2026-04-13

Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy

19 enrolled

Colonic Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT02465060 2026-04-13

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

6,452 enrolled 2 FDA

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT02688712 2026-04-13

ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer

50 enrolled

Phase 1/2 Active not recruiting

Rectal Neoplasms

NCT04287868 2026-04-13

Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

51 enrolled 16 charts

GastrointestinalGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Rectal Neoplasms

NCT04751370 2026-04-13

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

31 enrolled

Rectal Neoplasms

NCT04929028 2026-04-13

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

40 enrolled

Anus Neoplasms, Rectal Neoplasms, HIV Infections

NCT06417476 2026-04-13

Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer

66 enrolled

Rectal Neoplasms

NCT06837831 2026-04-13

Mepilex Lite Dressings for the Treatment of Acute Radiation Dermatitis of Anal Canal Skin

274 enrolled

Rectal Neoplasms

NCT07404228 2026-04-13

RESTAGE

Not yet recruiting

115 enrolled

Rectal Neoplasms

NCT07501845 2026-04-13

Registry Maastro Applicator

999 enrolled

Rectal Neoplasms

NCT03259035 2026-04-09

NEO: Neoadjuvant Chemotherapy, Excision and Observation for Early Rectal Cancer

Phase 2 Completed

58 enrolled 12 charts

Rectal Neoplasms

NCT04624555 2026-04-09

The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

50 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT06746012 2026-04-09

Designing a Dyad-Based mHealth Intervention to Improve Adherence to Lifestyle Recommendations in Colorectal Cancer Survivors and Their Family Caregivers

70 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT05462717 2026-04-08

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

GastrointestinalGynecologicThoracic

222 enrolled

Appendiceal Neoplasms, Bronchial Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Stomach Neoplasms, Thoracic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Carcinoma, Pancreatic Ductal

NCT06162650 2026-04-08

Total Neoadjuvant Therapy in Rectal Cancer

42 enrolled

Rectal Neoplasms

NCT05217446 2026-04-07

SEAMARK

107 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05983133 2026-04-07

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

GastrointestinalHead & NeckThoracic

68 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07283939 2026-04-07

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled