Clinical Trials Browser

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Esophageal Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03953976 2026-02-19

INRT-AIR: A Prospective Phase II Study of Involved Nodal Radiation Therapy

Phase 2 Completed

67 enrolled 16 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03993353 2026-02-12

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

Phase 2 Completed

7 enrolled 14 charts

GastrointestinalHead & Neck

Pyridoxine-dependent epilepsy, Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Esophageal Neoplasms, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms

NCT01932697 2026-02-10

Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer

Phase 2 Completed

81 enrolled 18 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT03474497 2026-01-29

UCDCC#272: IL-2, Radiotherapy, and Pembrolizumab in Patients Refractory to Checkpoint Blockade

Phase 1/2 Active not recruiting

18 enrolled 13 charts

DermatologicGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma

NCT03468218 2026-01-23

Pembrolizumab & Cabozantinib in Patients With Head and Neck Squamous Cell Cancer

Phase 2 Active not recruiting

36 enrolled 11 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03829722 2026-01-22

Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer

Phase 2 Completed

26 enrolled 13 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02296684 2026-01-15

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

Phase 2 Completed

67 enrolled 15 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04326257 2026-01-08

Personalized Immunotherapy in Patients With Recurrent /Metastatic SCCHN That Have Progressed on Prior Immunotherapy

Phase 2 Completed

20 enrolled 13 charts

Head & Neck

Diabetes Mellitus, Insulin-Dependent, 12, Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT01927744 2025-11-26

Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection

Phase 2 Completed

55 enrolled 8 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04454489 2025-11-19

Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition

Phase 2 Completed

21 enrolled 18 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02369458 2025-11-18

Mitomycin C in Patients With Incurable p16 Positive Oropharyngeal and p16 Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Resistant to Standard Therapies

Phase 2 Completed

48 enrolled 12 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03021993 2025-11-12

Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer

Phase 2 Completed

17 enrolled 15 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05057247 2025-10-31

Duvelisib Plus Docetaxel In Recurrent/Metastatic HNSCC

Phase 2 Completed

26 enrolled 23 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03049618 2025-10-22

Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475

Phase 2 Completed

42 enrolled 40 charts

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung

NCT06046482 2025-10-22

Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma

Phase 2 Terminated

4 enrolled 11 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02254278 2025-10-09

Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer

Phase 2 Completed

316 enrolled 31 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT03552965 2025-09-02

Margin-Based Vs. Robust Photon Radiotherapy Planning in IMRT of HN-SQCC

Phase NA Completed

23 enrolled 21 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Xerostomia

NCT00665392 2025-08-01

ECHO-07

Phase 2 Completed

42 enrolled 24 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Tongue Neoplasms

NCT02892201 2025-07-29

Pembrolizumab in HNSCC With Residual Disease After Radiation

Phase 2 Terminated

9 enrolled 15 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03795610 2025-07-25

IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma

Phase 2 Completed

16 enrolled 10 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms, Neoplasms

NCT04282109 2025-06-26

NIVOTAX

Phase 2 Completed

141 enrolled 40 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT03341936 2025-06-18

Neodjuvant Nivolumab and Lirilumab, Followed by Surgery, Followed by Adjuvant Nivolumab and Lirilumab, in SCCHN

Phase 2 Active not recruiting

29 enrolled 11 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT04555837 2025-05-20

Alisertib and Pembrolizumab for the Treatment of Patients With Rb-deficient Head and Neck Squamous Cell Cancer

Phase 1/2 Completed

24 enrolled 13 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03944915 2025-05-11

DEPEND

Phase 2 Completed

35 enrolled 14 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT03107182 2025-05-06

OPTIMA-II

Phase 2 Completed

72 enrolled 14 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03053960 2025-04-30

Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer

Terminated

8 enrolled 5 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03342911 2025-04-24

Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery

Phase 2 Completed

34 enrolled 10 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT04752384 2025-04-20

Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients

Phase 2 Completed

20 enrolled 10 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Mucositis

NCT02827838 2025-03-17

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

Phase EARLY_PHASE1 Terminated

17 enrolled 12 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT03602911 2025-03-12

A Comparison of NETSPOT Imaging Versus F-FDG-PET in Head and Neck Cancer Patients

Phase 2 Completed

20 enrolled 5 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT02289209 2025-03-06

Reirradiation With Pembrolizumab in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck

Phase 2 Completed

48 enrolled 18 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT00544414 2025-02-19

Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer

Phase 2 Completed

31 enrolled 8 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04030130 2025-01-29

NDURE2

Phase NA Completed

176 enrolled 19 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT04883645 2025-01-28

Neoadjuvant Imiquimod Immunotherapy for Oral Cancer

Phase EARLY_PHASE1 Completed

16 enrolled 10 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03459729 2025-01-16

Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer

Phase EARLY_PHASE1 Completed

6 enrolled 14 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03715946 2025-01-13

Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer

Phase 2 Completed

40 enrolled 69 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms