Clinical Trials Browser

Phase 1 × Vaccinia × Clear all

NCT05376527 2026-04-21

Open Multi-cohort Study of the First Phase of Safety of a Drug Based on Double Recombinant Vaccinia Virus VV-GMCSF-Lact

Phase 1 Completed

34 enrolled 18 charts

Breast Neoplasms, Vaccinia

NCT06910657 2026-03-02

IDOV-Immune for Advanced Solid Tumors

Phase 1 Recruiting

BreastDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Stomach Neoplasms, Vaccinia, Colorectal Neoplasms

NCT07001592 2025-06-03

RIOT3

Phase 1 Recruiting

Gastrointestinal

Esophageal Neoplasms, Liver Neoplasms, Stomach Neoplasms, Vaccinia

NCT00794131 2025-04-24

Safety Study of GL-ONC1, an Oncolytic Virus, in Patients With Advanced Solid Tumors

Phase 1 Completed

Neoplasms, Vaccinia

NCT03954067 2025-04-22

A Study of an Intratumoral Oncolytic Virus in Patients With Advanced Metastatic Solid Tumors

Phase 1 Completed

Neoplasm Metastasis, Vaccinia

NCT01169584 2016-01-21

Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors in Pediatric Patients

Phase 1 Completed

CNSGenitourinaryLymphoidSarcoma

Lymphoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Vaccinia, Neurofibrosarcoma

NCT01380600 2016-01-08

Safety Study of Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma

Phase 1 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Vaccinia, Colorectal Neoplasms

NCT00574977 2015-12-28

Safety Study of Modified Vaccinia Virus to Cancer

Phase 1 Completed

BreastDermatologicGastrointestinal

Adenocarcinoma, Breast Neoplasms, Liver Neoplasms, Melanoma, Neoplasms, Vaccinia, Virus Diseases, Colorectal Neoplasms, Neoplasms, Squamous Cell

NCT00625456 2015-12-03

Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors

Phase 1 Completed

DermatologicGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Lung Neoplasms, Melanoma, Vaccinia

NCT01584284 2015-08-25

Safety Study of Attenuated Vaccinia Virus (GL-ONC1)With Combination Therapy in Head & Neck Cancer

Phase 1 Completed

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Vaccinia

NCT00629759 2013-01-04

A Study of Recombinant Vaccinia Virus to Evaluate the Safety and Efficacy of a Transdermal Injection Within the Tumor of Patients With Primary or Metastatic Hepatic Carcinoma

Phase 1 Completed

Gastrointestinal

Carcinoma, Hepatocellular, Liver Neoplasms, Vaccinia