NCT04879121 2026-04-16Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid TumorsM.D. Anderson Cancer CenterPhase 2 Recruiting13 enrolled
NCT03155620 2026-04-14Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)National Cancer Institute (NCI)Phase 2 Active not recruiting1,377 enrolled 10 charts
NCT02465060 2026-04-13Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)National Cancer Institute (NCI)Phase 2 Active not recruiting6,452 enrolled 2 FDA
NCT04655404 2026-03-18A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK FusionNationwide Children's HospitalPhase EARLY_PHASE1 Recruiting15 enrolled
NCT02122913 2026-02-05A Study to Test the Safety of the Investigational Drug Larotrectinib in Adults That May Treat CancerBayerPhase 1 Completed75 enrolled 3 FDA