Clinical Trials

Phase 3 Active not recruiting

Rectal Neoplasms

NCT04543617 2026-04-17

SKYSCRAPER-07

760 enrolled

Esophageal Squamous Cell Carcinoma

NCT05862285 2026-04-13

UmbrellaMAX

Phase 3 Recruiting

100 enrolled

Tumor-Agnostic

Neoplasms

NCT04540211 2026-04-09

SKYSCRAPER-08

461 enrolled 24 charts

Esophageal Neoplasms

NCT04256421 2026-04-03

SKYSCRAPER-02

490 enrolled 33 charts

Small Cell Lung Carcinoma

NCT04929223 2026-03-31

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Phase 1 Recruiting

542 enrolled

Colorectal Neoplasms

NCT04524871 2026-03-27

MORPHEUS-LIVER

Phase 1/2 Recruiting

518 enrolled

Advanced Liver Cancers

NCT04300647 2026-03-12

SKYSCRAPER-04

172 enrolled 27 charts

Gynecologic

Uterine Cervical Neoplasms

NCT04832854 2026-03-11

A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer

Phase 2 Terminated

50 enrolled 18 charts

Phase 3 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT04665856 2026-02-13

SKYSCRAPER-02C

123 enrolled 26 charts

Phase 2 Active not recruiting

Small Cell Lung Carcinoma

NCT05805501 2026-02-12

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

199 enrolled

Genitourinary

Carcinoma, Renal Cell

NCT05661578 2026-02-09

SKYSCRAPER-11

64 enrolled

Other solid neoplasm

PD-L1-selected Solid Tumors

NCT04619797 2026-02-03

SKYSCRAPER-06

Phase 2/3 Completed

542 enrolled

Carcinoma, Non-Small-Cell Lung

NCT06267001 2026-02-03

SKYSCRAPER-15

56 enrolled

Carcinoma, Non-Small-Cell Lung

NCT04294810 2026-01-30

SKYSCRAPER-01

620 enrolled

Phase 2 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT05645692 2026-01-30

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

204 enrolled

Genitourinary

Urothelial Cancer

NCT03869190 2026-01-22

Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC)

272 enrolled

Genitourinary

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT03563716 2026-01-20

A Study of Tiragolumab in Combination With Atezolizumab in Chemotherapy-Naïve Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

135 enrolled 12 charts

Phase 3 Active not recruiting

Carcinoma, Non-Small-Cell Lung

NCT05904886 2025-12-31

SKYSCRAPER-14

687 enrolled

Carcinoma, Hepatocellular

NCT03281369 2025-12-15

A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

214 enrolled

Esophageal Neoplasms

NCT03337698 2025-12-12

Morpheus Lung

314 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05908786 2025-12-11

A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma

62 enrolled

Carcinoma, Hepatocellular

NCT03193190 2025-11-21

A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)

341 enrolled 28 charts

Pancreatic Adenocarcinoma

NCT04665843 2025-09-30

SKYSCRAPER-09

123 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT05459129 2025-09-15

A Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck (Morpheus-Head and Neck Cancer)

12 enrolled 18 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT04513925 2025-09-08

SKYSCRAPER-03

829 enrolled

Carcinoma, Non-Small-Cell Lung

NCT05116202 2025-07-18

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morpheus-Melanoma)

110 enrolled 27 charts

Dermatologic

Melanoma

NCT04632992 2025-01-08

MyTACTIC

252 enrolled 27 charts

Advanced Unresectable or Metastatic Solid Malignancy

NCT06331598 2024-12-24

IMperator

Phase 2 Withdrawn

Other solid neoplasm

Solid Tumors

NCT02794571 2024-12-05

Safety and Pharmacokinetics (PK) of Escalating Doses of Tiragolumab as a Single Agent and in Combination With Atezolizumab and/or Other Anti-Cancer Therapies in Locally Advanced or Metastatic Tumors

Phase 1 Completed

518 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT04933227 2024-11-14

A Study to Explore the Efficacy and Safety of Atezolizumab Plus Tiragolumab and Chemotherapy in 1st Line HER2 Negative Unresectable, Recurrent or Metastatic Gastric Cancer or Adenocarcinoma of Gastroesophageal Junction (GEJ)

Phase 2 Terminated

29 enrolled

Stomach Neoplasms

NCT05315713 2024-10-04

An Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Combination With Tiragolumab With or Without Atezolizumab in Participants With B-Cell Non-Hodgkin Lymphoma

Phase 1/2 Terminated

8 enrolled 12 charts

Lymphoid

Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoma, B-Cell

NCT04308785 2023-10-23

A Study of Atezolizumab With or Without Tiragolumab Consolidation in Limited Stage Small Cell Lung Cancer

Phase 2 Terminated

24 enrolled