Clinical Trials Browser

Interventional × sodium thiosulfate × Clear all

NCT07218913 2026-04-17

Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors

Phase 1 Recruiting

Testicular Neoplasms, Seminoma, Hearing Loss

NCT04847063 2026-04-14

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

Phase 1 Recruiting

GastrointestinalGynecologic

Appendiceal Neoplasms, Gastrointestinal Neoplasms, Necrosis, Ovarian Neoplasms, Peritoneal Neoplasms, Colorectal Neoplasms

NCT05382338 2026-02-24

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Phase 3 Recruiting

Medulloblastoma

NCT05756660 2025-10-20

Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy

Phase EARLY_PHASE1 Suspended

Gastrointestinal

Ototoxicity, Neoplasms, Germ Cell and Embryonal, Hepatoblastoma

NCT03127774 2025-10-03

Surgery and Heated Intraperitoneal Chemotherapy for Adrenocortical Carcinoma

Phase 2 Recruiting

EndocrineGynecologic

Peritoneal Neoplasms, Adrenocortical Carcinoma

NCT04478292 2025-05-18

A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy

Phase 3 Recruiting

Gastrointestinal

Hepatoblastoma

NCT01369641 2025-05-16

The Effect of Sodium Thiosulfate Eardrops on Hearing Loss in Patients Who Receive Cisplatin Therapy

Phase NA Terminated

1 enrolled 6 charts

Neoplasms

NCT04213794 2025-02-20

TOASTIT

Phase EARLY_PHASE1 Terminated

GastrointestinalGynecologicOther solid neoplasmSarcomaThoracic

Mesothelioma, Malignant, Colonic Neoplasms, Fallopian Tube Neoplasms, Liposarcoma, Ovarian Neoplasms, Pelvic Neoplasms, Rectal Neoplasms, Rhabdomyosarcoma, Sarcoma, Stomach Neoplasms, Desmoplastic Small Round Cell Tumor

NCT03092518 2025-02-19

Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology

Phase 2 Completed

27 enrolled 13 charts

Gastrointestinal

Adenocarcinoma, Stomach Neoplasms

NCT04541355 2024-06-28

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

Phase 2 Completed

16 enrolled 12 charts

Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00716976 2023-11-09

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy

Phase 3 Completed

131 enrolled 18 charts 2 FDA

CNSGastrointestinalGenitourinaryGynecologicSarcoma

Ovarian Germ Cell Cancer, Ototoxicity, Brain Neoplasms, Liver Neoplasms, Medulloblastoma, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Hepatoblastoma

NCT00074165 2023-07-06

Treating Patients With Recurrent PCNSL With Carboplatin/BBBD and Adding Rituxan To The Treatment Regimen

Phase 2 Terminated

17 enrolled 7 charts

CNSClassical hematologyLymphoid

Lymphoma, Thrombocytopenia, Central Nervous System Neoplasms, Intraocular Lymphoma, Drug-Related Side Effects and Adverse Reactions

NCT04262336 2023-07-06

Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment

Phase 1 Completed

Ototoxicity, Hearing Loss

NCT00075387 2022-05-03

Combination Chemotherapy With or Without Sodium Thiosulfate in Preventing Low Platelet Count While Treating Patients With Malignant Brain Tumors

Phase 2 Unknown

Glioma

NCT00303849 2022-03-17

Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors

Phase 1/2 Completed

Astrocytoma, Glioma, Oligodendroglioma

NCT05232357 2022-03-15

Endoscopic Vital Nerve Staining in Gastrointestinal Diseases

Phase EARLY_PHASE1 Unknown

Gastrointestinal

Gastrointestinal Neoplasms

NCT00983398 2021-10-26

Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors

Phase 1/2 Unknown

Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Neuroectodermal Tumors, Primitive

NCT02092298 2021-06-15

Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) for Metastatic Gastric Cancer

Phase 2 Completed

21 enrolled 7 charts

Gastrointestinal

Gastrointestinal Neoplasms

NCT01833832 2019-07-30

Surgery and Heated Chemotherapy for Adrenocortical Carcinoma

Phase 2 Completed

11 enrolled 14 charts

EndocrineGynecologic

Hyperthermia, Peritoneal Neoplasms, Adrenocortical Carcinoma

NCT00652132 2018-05-29

SIOPEL6

Phase 3 Completed

116 enrolled 2 FDA

Gastrointestinal

Ototoxicity, Liver Neoplasms, Hepatoblastoma

NCT00238173 2017-04-21

Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors

Phase 1 Terminated

Familial ependymoma, Astrocytoma, Medulloblastoma, Oligodendroglioma, Central Nervous System Neoplasms, Optic Nerve Glioma, Drug-Related Side Effects and Adverse Reactions

NCT00397501 2017-04-21

BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain

Phase 1/2 Withdrawn

Brain Neoplasms, Breast Neoplasms, Central Nervous System Neoplasms, Drug-Related Side Effects and Adverse Reactions

NCT00571298 2017-01-23

Extrapleural Pneumonectomy /Pleurectomy Decortication, IHOC Cisplatin and Gemcitabine With Amifostine and Sodium Thiosulfate Cytoprotection for Resectable Malignant Pleural Mesothelioma

Phase 1 Completed

Other solid neoplasmThoracic

Mesothelioma, Malignant, Mesothelioma

NCT00165503 2016-09-09

Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate

Phase 2 Terminated

16 enrolled 7 charts

Other solid neoplasmThoracic

Mesothelioma, Malignant

NCT00165516 2014-03-27

Extrapleural Pneumonectomy With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Amifostine and Sodium Thiosulfate

Phase 2 Completed

Other solid neoplasmThoracic

Mesothelioma, Malignant

NCT00165555 2014-03-27

Pleurectomy/Decortication Followed by Intrathoracic/Intraperitoneal Heated Cisplatin for Malignant Pleural Mesothelioma

Phase 1 Completed

Other solid neoplasmThoracic

Mesothelioma, Malignant