Clinical Trials

132 enrolled

Glioma

NCT05130801 2026-04-22

A Study of Multiparametric MRI and pHLIP® ICG in Breast Cancer Imaging During Surgery

55 enrolled

Breast Neoplasms

NCT05455619 2026-04-22

Amelia-1

52 enrolled

Breast Neoplasms, Hyperglycemia, Hyperinsulinism, Insulin Resistance

NCT05470491 2026-04-22

Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...

Other hematologic neoplasm

265 enrolled

Acquired Immunodeficiency Syndrome, Hematologic Neoplasms

NCT05642195 2026-04-22

Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

Phase 1/2 Suspended

30 enrolled

Carcinoma, Carcinoma, Non-Small-Cell Lung, Neoplasm, Residual

NCT05683834 2026-04-22

Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-seronegative Persons

Phase 1/2 Completed

25 enrolled

Herpes Simplex, Infectious Mononucleosis, Epstein-Barr Virus Infections

NCT05975073 2026-04-22

A Phase 1/2 Study of Anvumetostat in Combination With IDE397 in Participants With Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors

Phase 1/2 Completed

53 enrolled

Tumor-Agnostic

Neoplasms

NCT06303193 2026-04-22

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

Classical hematologyMyeloid

160 enrolled

Anemia, Aplastic, Anemia, Refractory, with Excess of Blasts, Bone Marrow Diseases, Myelodysplastic Syndromes, Myeloproliferative Disorders

NCT06614140 2026-04-22

Personalized Neoantigen Cancer Vaccine for Patients With Solid Tumors

Phase 1/2 Completed

8 enrolled

Tumor-Agnostic

Neoplasms

NCT06694454 2026-04-22

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

60 enrolled

Pathologic Complete Response, Carcinoma, Non-Small-Cell Lung

NCT06785636 2026-04-22

P300

252 enrolled

Genitourinary

Genital Neoplasms, Male, Neoplasms, Neoplasms by Site, Prostatic Diseases, Prostatic Neoplasms, Urogenital Neoplasms, Male Urogenital Diseases

NCT06876142 2026-04-22

Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma

Phase 1/2 Suspended

54 enrolled

Plasma cell

Multiple Myeloma

NCT06898450 2026-04-22

A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

134 enrolled

Werner Syndrome, Microsatellite Instability

NCT06922591 2026-04-22

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

183 enrolled

Lung Neoplasms

NCT06991738 2026-04-22

177Lu-DOTA-EB-TATE in Adult Patients With Metastatic, Radioactive Iodine Non-Responsive Oncocytic (Hurthle-Cell) Thyroid Cancer

18 enrolled

Head & Neck

Thyroid Neoplasms

NCT07020221 2026-04-22

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

295 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT07136779 2026-04-22

First-in-Human Trial of VBC101 in Participants With Advanced Solid Tumor Malignancies

310 enrolled

Other solid neoplasm

Participants With Advanced Solid Tumor Malignancies

NCT07243470 2026-04-22

TARLATEM

70 enrolled

Glioma, Central Nervous System Neoplasms

NCT07299747 2026-04-22

Clinical Trial of VBC103 in Patients With Advanced Malignant Solid Tumors

255 enrolled

Other solid neoplasm

Participants With Advanced Solid Tumor Malignancies

NCT07328490 2026-04-22

Bispecific T-Cell Engager Tarlatamab and TROP2 Targeted Antibody Drug Conjugate Sacituzumab Govitecan in Previously Treated Extensive-Stage Small Cell Lung Cancer and Extrapulmonary Neuroendocrine Cancer

120 enrolled

Carcinoma, Small Cell, Small Cell Lung Carcinoma

NCT07332455 2026-04-22

First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

54 enrolled

Genitourinary

Prostatic Neoplasms

NCT07416188 2026-04-22

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

40 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Neoplasms, Neoplasms by Histologic Type, Neoplasms, Nerve Tissue, Recurrence, Central Nervous System Neoplasms

NCT07472322 2026-04-22

ASTX727 & Retifanlimab-dlwr for Advanced Merkel Cell After Progression on Anti-PD-(L)1

31 enrolled

Dermatologic

Carcinoma, Merkel Cell

NCT07545265 2026-04-22

SKB565 for Injection in Advanced Solid Tumors

180 enrolled

Other solid neoplasm

Advanced Solid Tumors

NCT01589861 2026-04-21

PIKHER2

Phase 1/2 Terminated

24 enrolled

Breast Neoplasms

NCT01604889 2026-04-21

A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma

Phase 1/2 Terminated

50 enrolled

Dermatologic

Melanoma, Neoplasms, Skin Neoplasms

NCT01980277 2026-04-21

TAKTIC

Phase 1/2 Terminated

68 enrolled

Phase 1/2 Active not recruiting

Breast Neoplasms

NCT03837899 2026-04-21

Durvalumab and Tremelimumab for Pediatric Malignancies

50 enrolled 59 charts

Other hematologic neoplasm

Neoplasms, Hematologic Neoplasms

NCT03919240 2026-04-21

CAR-T Cell Therapy Targeting to CD19 for R/R ALL

LymphoidOther hematologic neoplasm

196 enrolled

Recurrence, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03919292 2026-04-21

Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca

83 enrolled

Gastrointestinal

Colonic Neoplasms, Pancreatic Neoplasms, Disease Progression

NCT04067336 2026-04-21

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

LymphoidOther hematologic neoplasm

263 enrolled 2 FDA

Leukemia, Leukemia, Biphenotypic, Acute, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04946370 2026-04-21

Phase I/II Trial of Pembrolizumab and Androgen-receptor Inhibitor With or Without 225Ac-J591 for Progressive Metastatic Castration Resistant Prostate Cancer

Phase 1/2 Active not recruiting

52 enrolled

Genitourinary

Prostatic Neoplasms

NCT05392946 2026-04-21

Iberdomide, Daratumumab, Bortezomib, and Dexamethasone for Treatment of Newly Diagnosed Multiple Myeloma, IDEAL Study

49 enrolled

Plasma cell

Multiple Myeloma

NCT05615623 2026-04-21

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG

Phase 1/2 Active not recruiting

10 enrolled

Brain Neoplasms

NCT05732831 2026-04-21

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

GastrointestinalOther solid neoplasmSarcomaThoracic

225 enrolled

Mesothelioma, Sarcoma, Cholangiocarcinoma, Neurofibrosarcoma

NCT05786924 2026-04-21

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

CNSGastrointestinalHead & NeckMyeloidThoracic

554 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Histiocytosis

NCT06137144 2026-04-21

PRIMAVERA

161 enrolled

Lymphoid

Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Lymphoma, T-Cell, Peripheral

NCT06239272 2026-04-21

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)